Ndiet induced obesity in rats pdf files

The most widely used models to induce obesity in rats are a lesion of the. Highfat dietinduced metabolic syndrome and oxidative stress in. In the present study, the methanolic extract of moringa oleifera leaves memol was evaluated for antiobesity activity in rats. Meal pattern analysis of dietinduced obesity in susceptible and resistant rats article pdf available in obesity research 117. We applied a comparative functional genomics approach to evaluate whether diet. Propensity to highfat diet induced obesity in rats is associated with changes in the gut microbiota gut inflammation august 2010 ajp gastrointestinal and liver physiology 2992. Stern, and jules hirsch rockefeller university, new york, new york 10021 faust, irving m. Dio in the context of alternative models of obesity. An external file that holds a picture, illustration, etc.

Lewcrl rats fed a 60% kcal hfd become obese, but they lack significant metabolic abnormalities frequently. Dietinduced obesity in rats leads to a decrease in sperm. For the study of these pathologies, a number of animal models have been developed. Longterm characterization of the dietinduced obese and diet. Highfat dietinduced obesity causes an inflammatory. I before the onset of obesity dio rats show an innate decreased sensitivity to the effects of damphetamine on icss threshold and feeding, as compared to dr rats. Rats genetically prone to dietinduced obesity dio and their counterpart dietresistant dr were fed a chow diet and their response to damphetamine on intracranial selfstimulation and food intake were assessed. Rats were fed a high fat diet and treated with a low dose of streptozotocin to create models of diet induced obesity or type 2 diabetes. Ii in a diet induced obesity state, dio rats show insensitivity to the damphetamine effect on icss, but show equal sensitivity. Wistar and sd rats were assigned for 2 experimental groups for 17 weeks.

Since rats and mice show a similar relationship, they are considered an appropriate model for studying dietary obesity. Adult male hooded rats which were offered a mixed, high energy diet for 90 days were hyperphagic and became significantly obese compared to chowfed control rats. Development of a new dietinduced obesity dio model using wistar lean rats. Obesity is rapidly becoming a worldwide epidemic that affects children and adults.

Highfat diet increases pain behaviors in rats with or. Highfat dietinduced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation. Placing obese rats on a normal diet improved glucose utilization. Pdf highfat dietinduced obesity causes an inflammatory. Biometric evidence of dietinduced obesity in lewcrl rats ncbi. Chronic central oxytocin infusion was carried out in high fat dietinduced obese rats. Propensity to highfat dietinduced obesity in rats is associated with. Pdf experimental model to induce obesity in rats researchgate.

Development of a new dietinduced obesity dio model using. It is intended to mimic the most common cause of obesity in humans. However, a direct comparison between wistar and spraguedawley sd rat as models of highfat hf dietinduced obesity has not been adequately evaluated so far. The data showed that hfdinduced obesity in lev rats was accompanied. This is likely to result from the additive effects of obesity and pregnancy on insulin sensitivity.

Mechanisms of the antiobesity effects of oxytocin in dietinduced. Some studies have shown a relationship between obesity and infertility, but until now it remains controversial. Pdf the etiology of obesity is multifactorial and is becoming a problem of. In a first experiment, male wistar rats were fed a highfat diet hfd. Pdf dietinduced obesity in rats leads to a decrease in sperm. Figure 1 shows body weight and cumulative food intake in the dio and dr rats fed either chow or he diet from weaning to.

Its impact on body weight, lipid metabolism and insulin. The same variables were then evaluated after exposing the rats to a highfat diet, after dio rats selectively developed obesity. The development of hypertension in a rat model of diet induced obesity is described in the literature. In the past decades, obesity and associated metabolic complications have reached epidemic proportions. Biometric evidence of dietinduced obesity in lewcrl rats. The classic rat strains for studying dietinduced obesity are wistar and spraguedawley. In this study, we used the paradigm of dietinduced obesity first described by woods et al. The dietinduced obesity model dio model is an animal model used to study obesity using animals that have obesity caused by being fed highfat or highdensity diets.

Pdf propensity to highfat dietinduced obesity in rats. Propensity to highfat dietinduced obesity in rats is associated with changes in the gut microbiota and gut. Typically mice, rats, dogs, or nonhuman primates are used in these models. Thus, the aim of the present study was to investigate the effect of highfat dietinduced obesity on male reproductive parameters. In this study, chronic administration of hfd in rats produced hypercholesterolemia 116. Dietinduced adipocyte number increase in adult rats. The dietinduced obesity model dio model is an animal model used to study obesity using animals that have obesity caused by being fed highfat or high density diets. Pdf meal pattern analysis of dietinduced obesity in. We examined whether reversal of high fat diet, stimulating weight loss, compared to two treatments previously shown to have beneficial effects, could improve glucose utilization and peripheral neuropathy in animal models of obesity and type 2 diabetes. However, a direct comparison between wistar and spraguedawley sd rat as models of highfat hf diet induced obesity has not been adequately evaluated so far. Antiobesity and hypolipidemic activity of moringa oleifera. Highfat diet consumption for 8 weeks affected body weight in longevans but not spraguedawley rats. The antiobesity potential of memol was studied against high fat dietinduced obesity hfd in rats.